详细介绍

张爽, 女, 博士, 讲师

联系方式:shuangzhang0402@163.com








教育经历:

20129-20176月   河南农业大学牧医工程学院    获学士学位

20179-20196月   河南农业大学牧医工程学院    获硕士学位(导师:杨国宇教授)

20199-20236月   河南农业大学动物医学院     获博士学位(导师:张改平院士)


工作经历:

202312-至今   beat365官方登录入口  抗病毒性传染病创新药物全国重点实验室  讲师


研究领域与兴趣

从事病毒感染致病分子机制研究,通过探索病毒感染后免疫及代谢等方面分子机制,为抗病毒创新药物研发提供宿主靶点


代表性论文:

1. Shuang Zhang. Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins[J].Journal of Medical Virology. 2023 Mar;95(3):e28591.

2. Shuang Zhang. PRRSV GP5 induced mitochondria-ER contact leading to mitochondrial ROS production facilitating PRRSV replication. mBio.2023 Dec 4;14(6):e0265123.

3. Sheng-Li Ming, Shuang Zhang, Qi Wang, et al. Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy. Autophagy. 2021 Nov 25:1-21.

4. Guo-Li Li, Ying-Qian Han, Bing-Qian Su, Hai-Shen Yu, Shuang Zhang; Guo-Yu Yang; Jiang Wang;Fang Liu,Sheng-Li Ming,Bei-Bei Chu. Porcine reproductive and respiratory syndrome virus 2 hijacks CMA-mediated lipolysis through upregulation of small GTPase RAB18. PLOS Pathogens. 2024 Apr 12;20(4):e1012123.

5. Sheng-Li Ming, Lei Zeng, Yu-Kun Guo, Shuang Zhang, et al.The human specific STING agonist G10 activates type I interferon and the NLRP3 inflammasome in porcine cells. 2020, Frontiers in Immunology; 24;11:575818.

6. Jiang Wang; Gen Ba; Ying-Qian Han; Sheng-Li Ming; Meng-Di Wang; Peng-Fei Fu; Qing-Qing Zhao; Shuang Zhang, et al. Cyclic GMP-AMP synthase is essential for cytosolic double-stranded DNA and fowl adenovirus serotype 4 triggered innate immune responses in chickens[J].Int.J.Biol.Macromol. 2019 Mar 01;146.



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