吕楠，男，博士，讲师

E-mail：lvnan@htu.edu.cn

教育经历：

2020-2024 厦门大学 理学博士

2017-2020 广东药科大学/中山大学（联合培养） 医学硕士

2010-2014 广东药科大学 理学学士

工作经历：

2014-2017 华兰生物股份有限公司  疫苗研发部                   研发员

2024-至今 beat365官方登录入口       抗病毒性传染病创新药物全国重点实验室  讲师

研究领域与兴趣：

理论与计算化学生物学、计算机辅助药物设计、生物信息学

主要研究蛋白-蛋白，蛋白-药物相互作机制、药物筛选与设计、分子动力学相关的算法开发，机器学习等

代表性论文：

(1)Lv, N.; Cao, Z. Subpocket-Based Analysis Approach for the Protein Pocket Dynamics. J. Chem. Theory Comput.2024, 20 (11), 4909–4920.

(2)Jiao, Q.; Ye, H.; Lv, N.; Huang, M.; Wu, R.; Yang, T.; Cao, Z.; Lei, Q.; Fang, W.; Xie, H. How the Strength of Proteins Interactions Affects the Phase Behavior of Protein Complexes. Food Hydrocoll.2024, 149, 109654. (Co-first)

(3)Liu, C.; Lv, N.; Song, Y.; Dong, L.; Huang, M.; Shen, Q.; Ren, G.; Wu, R.; Wang, B.; Cao, Z.; Xie, H. Interaction Mechanism between Zein and β-Lactoglobulin: Insights from Multi-Spectroscopy and Molecular Dynamics Simulation Methods. Food Hydrocoll.2023, 135, 108226. (Co-first)

(4)Liu, C.; Lv, N.; Xu, Y.-Q.; Tong, H.; Sun, Y.; Huang, M.; Ren, G.; Shen, Q.; Wu, R.; Wang, B.; Cao, Z.; Xie, H. pH-Dependent Interaction Mechanisms between β-Lactoglobulin and EGCG: Insights from Multi-Spectroscopy and Molecular Dynamics Simulation Methods. Food Hydrocoll.2022, 133, 108022. (Co-first)

(5)Lv, N.; Cao, Z. RBD Spatial Orientation of the Spike Protein and Its Binding to ACE2: Insight into the High Infectivity of the SARS-CoV-2 Delta Variant from MD Simulations. Phys. Chem. Chem. Phys.2022, 24 (39), 24155–24165.

(6)Liu, C.; Lv, N.; Ren, G.; Wu, R.; Wang, B.; Cao, Z.; Xie, H. Explore the Interaction Mechanism between Zein and EGCG Using Multi-Spectroscopy and Molecular Dynamics Simulation Methods. Food Hydrocoll.2021, 120, 106906. (Co-first)

(7)Wang, K.; Lyu, N.; Diao, H.; Jin, S.; Zeng, T.; Zhou, Y.; Wu, R. GM-DockZn: A Geometry Matching-Based Docking Algorithm for Zinc Proteins. Bioinformatics2020, 36 (13), 4004–4011. (Co-first)

(8)Lyu, N.; Wang, K.; Zhang, F.; Qin, H.; Zhao, Y.; Wu, R.; Si, Y.; Wang, L. Recognition of PDL1/L2 by Different Induced-Fit Mechanisms of PD1: A Comparative Study of Molecular Dynamics Simulations. Phys. Chem. Chem. Phys.2020, 22 (3), 1276–1287.