辛鹏洋,博士,副教授,博士生导师
河南省优秀青年科学基金获得者(2021年入选)
E-Mail:pyxin27@163.com
教育经历:
2012.9-2015.6 复旦大学 获博士学位
2009.9-2012.6 beat365官方登录入口 获硕士学位
2005.9-2009.6 许昌学院 获学士学位
工作经历:
2023.4-至今 beat365官方登录入口 抗病毒性传染病创新药物全国重点实验室
2022.10-2023.4 beat365官方登录入口 省部共建国家重点实验室(筹)
2015.7-2022.10 beat365官方登录入口 化学化工学院
研究领域与兴趣:
超分子化学、化学生物学。构建有机超分子体系模拟生物大分子的结构与功能,并进一步研究其在生物医药方面的潜在应用,在Acc. Chem. Res., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Green Chem.以及Chem. Commun.等国内外具有重要影响力的期刊上发表论文多篇。
近年来主持的主要科研项目:
1、国家自然科学基金-面上项目,2022,在研,主持
2、国家自然科学基金-联合基金,2020,结项,主持
3、河南省优秀青年科学基金,2021,结项,主持
4、河南省高等学校重点科研项目-基础研究专项,2021,在研,主持
5、beat365官方登录入口国家自然科学基金面上项目培育项目,结项,主持
6、国家自然科学基金青年基金,结项,主持
7、河南省2016年科技发展计划-基础与前沿技术研究,结项,主持
代表性论文:
1.Linlin Shi, Wen Zhao, Zhihui Jiu, Jingjing Guo*, Qiuhui Zhu, Yonghui Sun, Bo Zhu,Junbiao Chang, and Pengyang Xin*, Redox-Regulated Synthetic Channels: Enabling Reversible Ion Transport by Modulating the Ion-Permeation Pathway, Angew. Chem. Int. Ed. 2024, 63, e202403667.(通讯作者)
2.Bowen Ren, Yonghui Sun*, Pengyang Xin*, Recent advance in Artificial Anion Channels and Their Selectivity, ChemPlusChem, 2024, e202400466.(通讯作者)
3.Pengyang Xin*, Wenke Ren, Qiuhui Zhu, Jie Wang, Yonghui Sun*, Junbiao Chang and Gongming Zhu*, Synthetic cation channel: reconstructing the ion permeation pathway of TRPA1 in an artificial system, RSC Adv., 2024, 14, 26933-26937. (通讯作者)
4.Shouwei Zhang, Jinfeng Wang, Andriy Yaroshchuk, Qiujiao Du, Pengyang Xin, Merlin L. Bruening*, and Fan Xia*, Addressing Challenges in Ion-Selectivity Characterization in Nanopores, J. Am. Chem. Soc.2024, 146, 11036-11042.
5.Pengyang Xin,* Linqi Xu, Wenpei Dong, Linlin Mao, Jingjing Guo,* Jingjing Bi, Shouwei Zhang, Yan Pei, Chang-Po Chen*, Synthetic K+ Channels Constructed by Rebuilding the Core Modules of Natural K+ Channels in an Artificial System. Angew. Chem. Int. Ed., 2023, e202217859. (Hot Paper, 通讯作者,IF = 16.823)
6.Qishuo Zhong, Yin Cao, Xiaopan Xie, Yuhang Wu, Zhiqing Chen, Qiuping Zhang, Chunyan Jia, Zhen Wu, Pengyang Xin, Xiaosheng Yan, Zhiping Zeng, Changliang Ren*,Non-Covalently Stapled H+/Cl− Ion Channels Activatable by Visible Light for Targeted Anticancer Therapy, Angew. Chem. Int. Ed., 2023, 63, e202314666.
7.Jingjing Guo*, Yiqiong Bao, Mengrong Li, Shu Li, Lili Xi, Pengyang Xin, Lei Wu, Huanxiang Liu, Yuguang Mu, Application of computational approaches in biomembranes: From structure to function, WIREs Comput. Mol. Sci., 2023, 13, e1679.
8.Pengyang Xin,* Lingyu Zhao, Linlin Mao, Linqi Xu, Shuaimin Hou, Huiyuan Kong, Haodong Fang, Haofeng Zhu, Tao Jiang, Chang-Po Chen*, Effect of Charge Status on the Ion Transport and Antimicrobial Activity of Synthetic Channels. Synthetic Channels. Chem. Commun.,2020,56, 13796-13799.(通讯作者,IF = 5.996)
9.Pengyang Xin,* Huiyuan Kong, Yonghui Sun, Lingyu Zhao, Haodong Fang, Haofeng Zhu, Tao Jiang, Jingjing Guo, Qian Zhang, Wenpei Dong, Chang-Po Chen*,Artificial K+ Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: Tuning Cation Selectivity and Generating Membrane Potential, Angew. Chem. Int. Ed.,2019,58, 2779-2784. (通讯作者,IF = 12.102)
10.Pengyang Xin,* Si Tan, Yaodong Wang, Yonghui Sun, Yan Wang, Yuqing Xu and Chang-Po Chen*,Functionalized hydrazide macrocycle ion channels showing pH-sensitive ion selectivities, Chem. Commun.,2017,53, 625-628. (通讯作者,IF = 6.319)
11.Pengyang Xin,* Si Tan, Yonghui Sun, Qiaojv Ren, Wenpei Dong, Jingjing Guo, Tao Jiang and Chang-Po Chen,* One-pot formation of hydrazide macrocycles with modified cavities: an example of pH-sensitive unimolecular cation channels, Chem. Commun.,2017,53, 5322-5325.(通讯作者,IF = 6.319)
12.Pengyang Xin,* Yonghui Sun, Huiyuan Kong, Yaodong Wang, Si Tan, Jingjing Guo, Tao Jiang, Wenpei Dong* and Chang-Po Chen*,A unimolecular channel formed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity, Chem.Commun.,2017,53, 11492-11495. (通讯作者,IF = 6.319)
13.Min Zhang, Ping-Ping Zhu ,Pengyang Xin, Wen Si, Zhan-Ting Li, and Jun-Li Hou*,Synthetic Channel Specifically Inserts into the Lipid Bilayer of GramPositive Bacteria but not that of Mammalian Erythrocytes, Angew. Chem. Int. Ed.,2017,56, 2999-3003. (IF = 11.994)
14.Lingjun Li* , Qianqian Li, Shengqiang Ding,Pengyang Xin, Yuqin Zhang, Shenlong Huang and Guisheng Zhang*, ADP-ribosyl-N3: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds, Molecules,2017,22, 1346. (IF = 2.861)
15.Pengyang Xin, Pingping, Zhu, Pei Su, Jun-Li Hou* and Zhan-Ting Li*, Hydrogen-Bonded Helical Hydrazide Oligomer and Polymer That Mimic the Ion Transport of Gramicidin A, J. Am. Chem. Soc.,2014,136, 13078-13081.(第一作者, IF = 12.113)
16.Pengyang Xin, Liang Zhang, Pei Su, Jun-Li Hou* and Zhan-Ting Li*, Hydrazide macrocycles as effective transmembrane channels for ammonium. Chem. Commun.,2015, 47,11140-11142. (第一作者,IF = 6.834)
17.Peng-Yang Xin, Hong-Ying Niu, Gui-Rong Qu* Rui-Fang Ding, Hai-Ming Guo*, Nickel catalyzed alkylation of N-aromatic heterocycles with Grignard reagents through direct C–H bond functionalization. Chem. Commun.,2012,48, 6717- 6719. (第一作者,IF = 6.834)
18.Gui-Rong Qu,*Peng-Yang Xin,Hong-Ying Niu, Dong-Chao Wang, Rui-Fang Ding, Hai-Ming Guo*, Nickel-catalyzed sp2C–H bonds arylation of N-aromatic heterocycles with Grignard reagents at room temperature. Chem. Commun.,2011,47,11140-11142. (除导师外第一作者,IF = 6.834)
19.Hai-Ming Guo,*Peng-Yang Xin, Hong-Ying Niu, Gui-Rong Qu*, Microwave irradiated C6-functionalization of 6-chloropurine nucleosides with various mild nucleophiles under solvent-free conditions. Green Chem.,2010,12, 2131-2134. (除导师外第一作者,IF = 8.02)
20.Gui-Rong Qu,*Peng-Yang Xin, Hong-Ying Niu,Hai-Ming Guo,* Microwave promoted palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of 6-chloropurines with sodium tetraarylborate in water. Tetrahedron,2011,67,9099- 9103. (除导师外第一作者,IF = 2.803)
21.Yingtang Zhang,* Pengyang Xin,*Qiufeng Yao, Electrochemical performance of LiFePO4/C synthesized by sol-gel method as cathode for aqueous lithium ion batteries. J. Alloy. Compd.,2018,74,404-408. (通讯作者,IF = 3.779)
22.Wen Si, Pengyang Xin, Zhan-Ting Li, Jun-Li Hou,* Tubular Unimolecular Artificial Transmembrane Channels: Construction Strategies and Transport Activities. Acc. Chem. Res.,2015,48,1612-1619. (IF = 22.323)
23.Qian Zhang,*Chun-Hang Zhang, Jun-Hui Yang, Peng-Yang Xin, Xiao-Peng Xuan, Jian-Ge Wang, Na-Na Ma, Hai-Ming Guo and Gui-Rong Qu, A four-unit [c2]daisy chain connected by hydrogen bonds. Chem. Commun.,2015,51, 15253-15256.(IF = 6.834)
24.Yu-Qin Jiang, Kai Wu, Qian Zhang, * Ke-Qing Li, Yan-Yan Li, Peng-Yang Xin, Wei-Wei Zhang and Hai-Ming Guo*, A dual-responsive hyperbranched supramolecular polymer constructed by cooperative host–guest recognition and hydrogen-bond interactions. Chem. Commun.,2018,54, 13821-13824.(IF = 6.834)
25.辛鹏洋,牛红英,渠桂荣,杨西宁,郭海明,*四芳基硼钠的简便合成.合成化学,2011,19,671-672.
26.祝平平,辛鹏洋,侯军利*,黎占亭*,乙酰胆碱经人工通道的跨膜输送.Chin. J. Org. Chem.,2015,35, 1994-1998.
27.祝平平,辛鹏洋,侯军利*,黎占亭*,间苯二甲酸自组装形成的人工跨膜离子通道.中国科学:化学,2015,45,624-628.
28.郭海明*,李璞,辛鹏洋,王东超,牛红英,渠桂荣*,微波促进的6-位磷功能化的非环嘌呤核苷类似物的合成.中国科学:化学,2010,40, 963-966.