白大昌 博士，副教授，硕士生导师

        本科郑州大学化学系，博士毕业于中国科学院上海有机化学研究所，获2020年“Thieme Chemistry Journal Award”国际学术期刊奖，2020年 河南省优秀青年基金，邮箱地址：baidachang@126.com.

教育经历：

2005.09 - 2009.07: 郑州大学，化学专业，理学学士

2009.09 - 2014.07: 中国科学院上海有机化学研究所，有机化学专业，理学博士（硕博连读），导师：侯雪龙 研究员

工作经历：

2014.07 - 2015.08: 中科院上海有机所金属有机国家重点实验室，助理研究员

2015.10–2016.10: 美国内布拉斯加医学研究中心，博士后

2016.11-2020.04：beat365官方登录入口，讲师

2020.04-至今：beat365官方登录入口，副教授

研究兴趣和领域：

1，发展以绿色合成化学为导向的新反应方法和技术，研究过渡金属催化（铜，镍，铑，钯）的新型反应模式，包括不对称催化反应体系。

2，致力于新反应方法学的发展及其选择性调节与控制，将发展的方法应用到药物分子的合成中。

近年来主持的主要科研项目:

1， 国家自然科学基金-青年项目，铜催化肟酯与缺电子烯烃的环加成反应，2019-2021， 26万

2.    河南省优秀青年科学基金，过渡金属催化不对称C-C/C-O 键活化反应研，2020-2023，25万元

3，河南省高等学校重点科研项目计划，具有C2对称的手性联苯类环戊二烯基铑络合物的合成及其应用研究，2018-2019，5万

代表性论文：

1.Bai, Da-Chang.*; Wu, Fen.; Chang, Ling-Na.;Wang, Man-Man.; Wu, Hao.; Chang, Jun-Biao.* Highly Regio- and Enantioselective Hydrosilylation of gem-Difluoroalkenes by Nickel Catalysis. Angew. Chem. Int. Ed.  2022,61, e202114918.  (IF = 15.336, Highlight by Synfacts 2022, 18, 0398)

2.Bai, Da-Chang.*; Yu, Yan-Jiang.; Guo, Hai-Ming.; Chang, Jun-Biao.; Li, Xing-Wei.* Nickel(0)-Catalyzed Enantioselective [3+2] Annulation of Cyclopropenones and a,b-Unsaturated Ketones/Imines.Angew. Chem. Int. Ed.  2020, 59, 2740-2744. (IF = 12.257, Highlight by Synfacts 2020.16.641)

3. Bai, Da-Chang.; Wang, Xue-Li.; Zheng, Guang-Fan.; Li, Xing-Wei.* Redox-Divergent Synthesis of Fluoroalkylated Pyridines and 2-Pyridones through Cu-Catalyzed N-O Cleavage of Oxime Acetates. Angew. Chem. Int. Ed. 2018, 57, 6633-6637. (IF = 12.257)

4. Bai, Da-Chang.*;Xu, Teng.; Ma, Chao-Rui.; Zheng, Xin.; Liu, Bing-Xian.; Xie, Fang.; Li, Xing-Wei.* Rh(III)-Catalyzed Mild Coupling of Nitrones and Azomethine Imines with Alkylidenecyclopropanes via C−H Activation: Facile Access to Bridged Cycles.  ACS Catal. 2018, 8, 4194-4200.  (IF = 11.384)

5. Bai, Da-Chang. ^(#); Xia, Jin-Tao. ^(#); Song, Fang-Fang .; Li, Xue-Yan .; Liu, Bing-Xian.; Liu, Li-Hong.; Zheng, Guang-Fan.; Yang, Xi-Fa.; Sun, Jia-Qiong, * Li, Xing-Wei.* Rhodium(III)-catalyzed diverse [4 + 1] annulation of arenes with 1,3-enynes via sp³/sp² C–H activation and 1,4-rhodium migration. Chem. Sci. 2019, 10. 3987-3993.(#: co-first authors, IF = 9.556)

6. Bai, Da-Chang.; Yu, Fei-Le.; Wang, Wan-Ying.; Chen, Di.; Li, Hao.; Liu, Qing-Rong.; Ding, Chang-Hua.; Chen, Bo.*; Hou, Xue-Long.* Palladium/N-heterocyclic carbene catalysed region and diastereoselective reaction of ketones with allyl reagents via inner-sphere mechanism. Nature Communications 2016, 7, 11806-11817. (IF = 12.353)

7. Yu, Fei-Le.^(#); Bai, Da-Chang.^(#) ; Liu, Xiu-Yan.^(#); Jiang, Yang-Jie.; Ding, Chang-Hua.*; Hou, Xue-Long.* Pd-Catalyzed Allylic Alkylation of gem-Alkyl, Aryl-Disubstituted Allyl Reagents with Ketones: Diastereoselective Construction of Vicinal Tertiary and Quaternary Carbon Centers. ACS Catal. 2018, 8, 3317–3321.(#: co-first authors, IF = 11.384)

8. Bai, Da-Chang.;*  Liu, Song.; Chen, Jun-Yan.; Yu, Yan-Jiang.; Wang, Man-Man.; Chang, Jun-Biao.; Lan., Yu.;* Li, Xing-Wei.* Mechanistic studies on nickel-catalyzed enantioselective [3 + 2] annulation for γ-butenolide synthesis via C–C activation of diarylcyclopropenones.Org. Chem. Front., 2021, 8, 3023-3031.

9.Bai, Da-Chang.;* Chen, Jun-Yan.; Zheng, Bing-Bing.;  Li, Xue-Yan.; Chang, Jun-Biao*. Catalytic [3+3] Annulation of β-Ketoethers and Cyclopropenones via C(sp3)-O/C-C Bond Cleavage under Transition-Metal Free Conditions.Chin. J. Chem. 2021, 39, 2769—2773

10.Chen, Junyan.; Bai, Da-Chang.;^* Guo, Xiuli.; Wang, Yiyao.;Li, Xingwei.* Diastereodivergent [4+2] Annulation of Biphenylenes with Enones via Nickel(0)-catalyzed C-C bond Activation. Chin Chem Lett. 2022. doi:10.1016/j.cclet.2022.02.079.

11. Cui, Yixin.; Bai, Da-Chang.;* Liu,Bingxian.;Chang, Junbiao.;*Li, Xingwei.* Rh(III)-Catalyzed Acylation of Heteroarenes with Cyclobutenones via C–H/C–C Bond Activation. Chem. Commun., 2020, 56, 15631--15634.

12.Xu, Gui-Qing.; Chen, Qi.; Wu, Fen.; Bai, Da-Chang.;* Chang, Jun-Biao.;* Li, Xing-Wei.* Rh(III)-Catalyzed Chemodivergent Coupling of N‑Phenoxyacetamides and Alkylidenecyclopropanes via C−H Activation.Org. Lett. 2021, 23, 2927−2932.

13.Bai, Da-Chang.; Jia, Qing-Qian.; Xu, Teng.; Zhang, Qiu-Qiu.; Wu, Fen.; Ma, Chao-Rui.; Liu, Bing-Xian.; Chang, Jun-Biao.*; Li, Xing-Wei.* Rhodium(III)-Catalyzed C−H Activation of Nitrones and Annulative Coupling with Nitroalkenes. J. Org. Chem. 2017, 82, 9877-9884.（IF= 4.849）

14. Bai, Da-Chang.; Liu, Xiu-Yan.; Li, Hao.; Ding，Chang-Hua.*; Hou, Xue-Long.* Tandem Thorpe Reaction/Palladium Catalyzed Asymmetric Allylic Alkylation: Access to Chiral β-enaminonitriles with Excellent Enantioselectivity. Chemistry-An Asian Journal  2017, 12, 212-215.（IF = 3.692）

15. Bai, Da-Chang.^(#); Wang, Wan-Ying.^(#); Ding, Chang-Hua.; Hou, Xue-Long*. Kinetic Resolution of Allyl Carbonates Using TMSCN as Nucleophile via Pd-Catalyzed Asymmetric Allylic Alkylation. Synlett. 2015, 26, 1510-1514.(#:co-first authors, IF = 2.419）

16. Li, Xue-Yan.; Yu, Yan-Jiang.; Qi, Ruo-Bing.; Bai, Da-Chang*. Facile access to fluoroalkylated 2-aminopyridines by Cu-catalyzed [3 + 3] couplings of oxime esters with β-CF3 acrylonitrile. Tetrahedron Lett. 2020. 61, 151858-151861. (IF = 2.259)

17.Cheng, Ruo-Shi.; Bai, Da-Chang.* Enantiodivergent Relay Coupling for Nickel-Catalyzed Stereoselective Functionalization of Cyclopropylzinc Reagents.Chin. J. Org. Chem. 2021, 41, 1746-1748.

18. Dai, Hong-Xue.; Wu, Fen.; Bai, Da-Chang*. Recent Advances in Ni-Catalyzed C-C bond Activation Reactions. Chin. J. Org. Chem. 2020. 40. 1423-1436.

19.Yang, Si-Qi.; Li, Xin.; Peng, Zhuo-Jin.; Yu, Wen-Yan.; Wang, Guang-Xu.; Jin, Ya-Lan.; Zheng, Bing-Bing.; Dai, Hong-Xue.; Bai, Da-Chang.* Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed [3＋3]Cycloaddition Reaction of Oxime Acetates.Chin. J. Org. Chem. 2019, 39, 1623-1629.

20.Huang, Shuai.; Tong, Fei-Fei.;  Bai, Da-Chang.; Zhang, Gao-Peng.; Jiang, Yang-Jie.; Zhang, Bo.; Leng, Xue-Bing.; Guo, Yin-Long.; Wan, Xiao-Long.; Zhang, Xin-Gang.;* Ding, Chang-Hua.;* Hou, Xue-Long.* Regio- and enantioselective umpolung gemdifluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand. Nat. Commun., 2021, 12, 6551.

21.Tian, Miao-Miao.; Bai, Da-Chang.; Zheng, Guang-Fan.; Chang, Jun-Biao.; Li, Xing-Wei.* Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C−H Activation and Nucleophilic Cyclization. J. Am. Chem. Soc. 2019, 141, 9527−9532. 

22. Sun, Jia-Qiong.; Bai,  Da-Chang.; Wang, Pei-Yuan.; Wang,  Kuan.;   Zheng, Guang-Fan.;  Li,  Xing-Wei. *Org. Lett. 2019, 21, 1789−1793. 

23.Wang, Man-Man.; Bai, Da-Chang.; Kong, Ling-Heng.; Liu, Bing-Xian.; Li, Xing-Wei.* Ag(I)-Catalyzed Nucleophilic Addition and Friedel-Crafts Alkylation between α-Oxo Ketene Dithioacetals and Propargylic Carbonates. Org. Lett. 2018, 20, 7775-7778.