张新迎

博士，教授，博士生导师。

电话：0373-3329261；E-mail：xinyingzhang@htu.cn

教育与工作经历：

1987.09-1991.06   beat365官方登录入口，化学专业，理学学士

1991.09-1994.06   beat365官方登录入口，有机化学专业，理学硕士

1994.07-2004.07   beat365官方登录入口，助教、讲师、副教授

2004.08-2006.12   美国北亚利桑那大学及马里兰大学，访问学者

2007.01-2007.08   beat365官方登录入口，副教授

2007.09-2010.06   beat365官方登录入口，环境科学专业，工学博士

2010.07 至今   beat365官方登录入口，教授

主讲课程：
物理有机化学；高等有机化学；有机化学实验

研究领域与兴趣：
1. 绿色合成新方法研究
2. 新型核苷衍生物的绿色合成及生物活性研究

近年来主持的主要科研项目:

1. 河南省高校科技创新团队支持计划（20IRTSTHN005）：有机功能分子的绿色合成及性能研究，2020.01-2021.12。

2. 河南省高校科技创新人才支持计划（15HASTIT005）：噻吩、呋喃及吡喃并嘧啶双环核苷的绿色合成及性能研究，2015.01-2017.12。

3. 国家自然科学基金项目（21172057）：新型六元杂环并嘧啶双环核苷的设计、合成及生物活性研究，2012.01-2015.12。

4. 河南省基础与前沿技术研究项目（092300410237）：嘧啶核苷—氢化喹啉杂化体的合成及生物活性研究。

5. 河南省国际科技合作项目（094300510054）：5-取代嘧啶碳环核苷的合成及抗病毒活性研究。

6. 河南省教育厅自然科学基金项目（2009A150017）：新型核苷类似物的绿色合成及生物活性研究。

代表性论文：

35. Yuanshuang Xu, Mengyang Shen, Xinying Zhang*, and Xuesen Fan*. Selective Synthesis of Pyrazolo[1,2-a]pyrazolones and 2-Acylindoles via Rh(III)-Catalyzed   Tunable Redox-Neutral Coupling of 1-Phenylpyrazolidinones with Alkynyl Cyclobutanols. Org. Lett., 2020, 22, 4697-4702.

34. Linghua Zhang, Yuanshuang Xu, Xiaopeng Zhang, Xinying Zhang*, and Xuesen Fan*. Synthesis of Pyrazolone Fused Benzodiazepines via Rh(III)-Catalyzed [4 + 3] Annulation of 1-Phenylpyrazolidinones with Propargyl Alcohols. Org. Chem. Front., 2020, 7, 2284-2290.

33. Yuanshuang Xu, Linghua Zhang, Mengyang Liu, Xiaopeng Zhang, Xinying Zhang*, and Xuesen Fan*. Synthesis of Benzoazepine Derivatives via Rh(III)-catalyzed Inert C(sp²)-H Functionalization and [4 + 3] Annulations. Org. Biomol. Chem., 2019, 17, 8706-8710.

32. Cai Gao, Bin Li, Xueyang Geng, Qianting Zhou, Xinying Zhang*, and Xuesen Fan*. Two Birds with One Stone: One-pot Simultaneous Synthesis of 2,2,2-Trifluoroethyl phenanthridines and Benzochromenones Featuring the Utilization of the Byproduct of Togni’s Reagent. Green Chem., 2019, 21, 5113-5117.

31. Xi Chen, Muhua Wang, Xinying Zhang*, and Xuesen Fan*. Rh(III)-Catalyzed Cascade Reactions of Sulfoxonium Ylides with α-Diazocarbonyl Compounds: An Access to Highly Functionalized Naphthalenones. Org. Lett., 2019, 21, 2541-2545.

30. Qianqian Wang, Xinying Zhang*, and Xuesen Fan*. Synthesis of 2-Aminobenzophenones through Acylation of Anilines with α-Oxocarboxylic Acids Assisted by tert-Butyl Nitrite. Org. Biomol. Chem., 2018, 16, 7737-7747.

29. Xia Song, Cai Gao, Xinying Zhang*, and Xuesen Fan*. Synthesis of Diversely Functionalized 2H-Chromenes through Pd-Catalyzed Cascade Reactions of 1,1-Dibromoolefin Derivatives with Arylboronic Acids. J. Org. Chem., 2018, 83, 15256-15267.

28. Xia Song, Cai Gao, Bin Li, Xinying Zhang*, and Xuesen Fan*. Regioselective Synthesis of 2-Alkenylindoles and 2-Alkenylindole-3-carboxylates through the Cascade Reactions of N-Nitrosoanilines with Propargyl Alcohols. J. Org. Chem., 2018, 83, 8509-8521.

27. Yuanshuang Xu, Bin Li, Xinying Zhang*, and Xuesen Fan*. One-Pot Synthesis of Fused N,O-Heterocycles through Rh(III)-Catalyzed Cascade Reactions of Aromatic/Vinylic N-Alkoxyamides with 4-Hydroxy-2-alkynoates. Adv. Synth. Catal., 2018, 360, 2613-2620.

26. Qianqian Wang, Zhangxin Wang, Xinying Zhang*, and Xuesen Fan*. Microwave-Promoted Metal-Free α-Alkylation of Ketones with Cycloalkanes through Cross-Coupling of C(sp3)-H Bonds. Asian J. Org. Chem., 2017, 6, 1445-1450.

25. Yuanshuang Xu, Bin Li, Xinying Zhang*, and Xuesen Fan*. Metal-Free Synthesis of 2-Aminobenzothiazoles via Iodine-Catalyzed and Oxygen-Promoted Cascade Reactions of Isothiocyanatobenzenes with Amines. J. Org. Chem., 2017, 82, 9637-9646.

24. Qianqian Wang, Zhangxin Wang, Yuanshuang Xu, Xinying Zhang,* and Xuesen Fan*. Bu₄NI-Catalyzed and ^tBuOOH-Oxidized Esterification of Aldehydes with Alkyl Halides in Water. Asian J. Org. Chem., 2016, 5, 1304-1308.

23. Shitao Duan, Yuanshuang Xu, Xinying Zhang*, and Xuesen Fan*. Synthesis of 2,2’-Biphenols through Direct C(sp²)–H Hydroxylation of [1,1’-biphenyl]-2-ols. Chem. Commun., 2016, 52, 10529-10532.

22. Xinying Zhang*, Zhangxin Wang, Xuesen Fan*, and Jianji Wang. Synthesis of Ketones through Microwave Irradiation Promoted Metal-free Alkylation of Aldehydes by Activation of C(sp3)−H Bond. J. Org. Chem., 2015, 80, 10660-10667.

21. Xinying Zhang*, Xiaojie Guo, and Xuesen Fan*. Synthesis of 2-Aminoquinoline-3-carboamides and Pyrimido[4,5-b]quinolin-4-ones through Copper-Catalyzed One-pot Multicomponent Reactions. Chem. Asian J., 2015, 10, 106-111.

20. 宰文静，蒋盼盼，张新迎*，Philippe M. Loiseau，郭胜海，范学森*. 嘧啶核苷-查尔酮杂化体的合成及其抗利什曼原虫活性研究. 有机化学, 2015, 35, 1335-1341.

19. Yan He, Xinying Zhang*, and Xuesen Fan*. One-pot Cascade Reactions of 1-Arylpenta-3,4-dien-2-ones Leading to 2-Arylphenols and Dibenzopyroanones. Chem. Commun., 2014, 50, 14968-14970.

18. Xinying Zhang,* Yunping Song, Lin Gao, Xiaojie Guo, and Xuesen Fan*. Highly Facile and Regio-selective Synthesis of Pyrazolo[1,5-a]pyrimidines via Reactions of 1,2-Allenic Ketones with Aminopyrazoles. Org. Biomol. Chem., 2014, 12, 2099-2107.

17. Xinying Zhang*, Xiaojie Guo, Liangliang Fang, Yunping Song, and Xuesen Fan*. Copper-catalyzed N- and O-arylation of Amides: Alternative Approaches to 3,4- Dihydroquinolin-2-ones, Quinolin-2-ones, and 12H-Chromeno[2,3-b]quinolin-12-ones. Eur. J. Org. Chem., 2013, 8087-8093.

16. Yan He, Xinying Zhang*, Liangyan Cui, Jianji wang, and Xuesen Fan*. Catalyst-free Synthesis of Diversely Substituted 6H-Benzo[c]chromenes and 6H-Benzo[c]-chromen-6-ones in Aqueous Media under MWI. Green Chem., 2012, 14, 3429-3435.

15. Haiyun Xu, Xinying Zhang*, Yan He, Shenghai Guo, and Xuesen Fan*. Tandem Reaction of 3-Hydroxyhexa-4,5-allenic Esters: a Novel Access to Diversely Substituted 2H-Pyran-2-ones and Indenes. Chem Commun., 2012, 48, 3121-3123.

14. Xinying Zhang*, Xuefei Jia, Jianji Wang, and Xuesen Fan*. An Economically and Environmentally Sustainable Synthesis of 2-Aminobenzothiazoles and 2-Aminobenzoxazoles Promoted by Water. Green Chem., 2011, 13, 413-418.

13.Xinying Zhang,* Xuefei Jia, Liangliang Fang, Nan Liu, Jianji Wang, and Xuesen Fan*. Tandem Reactions of 1,2-Allenic Ketones Leading to Substituted Benzenes and α,β-Unsaturated Nitriles.Org. Lett., 2011, 13, 5024-5027.

12. Xuesen Fan*, Yangyang Wang, Yingying Qu, Haiyun Xu, Yan He, Xinying Zhang*, and Jianji Wang. Tandem Reactions Leading to Bicyclic Pyrimidine Nucleosides and Benzopyran-4-ones. J. Org. Chem., 2011, 76, 982-985.

11. Xinying Zhang*, Dongfang Li, Xuefei Jia, Jianji Wang, and Xuesen Fan*. CuI/[bmim]OAc in [bmim]PF₆: a Highly Efficient and Readily Recyclable Catalytic System for the Synthesis of 2,3-Disubstituted Benzo[b]furans. Catal. Commun., 2011, 12, 839-843.

10. Xinying Zhang, Dongfang Li, Xuesen Fan*, Xia Wang, Xiaoyan Li, Guirong Qu*, Jianji Wang. Ionic Liquid-promoted Multi-component Reaction: Novel and Efficient Preparation of Pyrazolo[3,4-b]pyridineone, Pyrazolo[3,4-b]quinolinone and their Hybrids with Pyrimidine Nucleoside. Mol. Divers., 2010, 14, 159-167.

9. Xinying Zhang, Yingying Qu, Xuesen Fan*, C. Bores, Dong Feng, Graciela Andrei, Robert Snoeck, Erik De Clercq, and Philippe M. Loiseau. Solvent-free Synthesis of Pyrimidine Nucleoside-aminophosphonate Hybrids and their Biological Activity Evaluation. Nucleosides, Nucleotides and Nucleic Acids.,2010, 29, 616-627.

8. Xinying Zhang, Xiaoyan Li, Dongfang Li, Guirong Qu*, Jianji Wang, Xuesen Fan*.  Ionic Liquid Mediated and Promoted Eco-friendly Preparation of Thiazolidinone and Pyrimidine Nucleoside-thiazolidinone Hybrids and Their Antiparasitic Activities. Bioorg. Med. Chem. Lett., 2009, 19, 6280-6283.

7. Xinying Zhang*, Xiaoyan Li, Xuesen Fan*, Xia Wang, Jianji Wang and Guirong Qu. Controllable Synthesis of Pyrazolo[3,4-b]pyridines or Substituted Malononitrile Derivatives through Multi-component Reactions in Ionic Liquid. Aust. J. Chem.,2009, 62, 382-388.

6. Xinying Zhang, Adel Amer, Xuesen Fan, Jan Balzarini, Johan Neyts, Erik De Clercq, Mark Prichard, Earl Kern and Paul F. Torrence*. Synthesis and Antiviral Activities of New Acyclic and “Double-Headed” Nucleoside Analogues. Bioorg. Chem., 2007, 35, 221-232.

5. Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Earl R. Kern, and Paul F. Torrence*.5-(Dimethoxymethyl)-2'-deoxyuridine: a Novel Gem Diether Nucleoside with Anti-orthopoxvirus activity. J. Med. Chem., 2006, 49, 3377-3382.

4. Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Mark N. Prichard, Earl R. Kern, and Paul F. Torrence*.Toward Orthopoxvirus Countermeasures: a Novel Heteromorphic Nucleoside of Unusual Structure. J. Med. Chem., 2006, 49, 4052-4054.

3. Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Earl R. Kern, and Paul F. Torrence*. Assembling a Smallpox Biodefense by Interrogating 5-Substituted Pyrimidine Nucleoside Chemical Space. Antiviral Res., 2006, 71, 201-205. 

2. Xinying Zhang*, Lingjun Li and Guisheng Zhang. An Efficient and Green Procedure for the Preparation of Acylals from Aldehydes Catalyzed by Fe₂(SO₄)₃·xH₂O. Green Chem., 2003, 5, 646-648.

1. Xinying Zhang, Xuesen Fan, Hongying Niu and Jianji Wang*. An Ionic Liquid as a Recyclable Medium for the Green Preparation of α,α’-Bis(substituted benzylidene)cycloalkanones Catalyzed by FeCl₃·6H₂O. Green Chem., 2003, 5, 267-269.